Target Safety Assessments
Our Target Safety Assessments offer a systematic, quantified approach to help users understand risks and plan appropriate mitigations. Assessing target safety at an early stage is crucial: users need to understand the mechanisms and phenotypes that could lead to adverse reactions and regulatory setbacks in later stages. This guides the de-risking assay roadmap, to ensure that only safer drug targets advance through the development pipeline.
An effective target safety assessment helps scientists synthesise a broad range of key evidence types, including relevant clinical studies, genetic and experimental evidence alongside multiple forms of literature-derived information. It summarises evidence directly or indirectly related to the target.
Additional safety information comes from the nature of the target itself, as well as the expected direction of modulation .